The Efficacy of Subgingivally Delivered Andrographis Paniculata Gel to Treat Patients with Periodontitis
Journal of Research and Practice in Dentistry
This study compared the clinical effects of scaling and root planing (SRP) after the adjunctive subgingival administration of Andrographis paniculata (AP) gel or placebo (PB) gel in a 6-month clinical trial for patients with chronic periodontitis. The study was a splitmouth, single-blind, randomized and controlled clinical trial that compared two treatment modalities (SRP+PB and SRP+AP) in single-rooted teeth with a probing depth (PD) of 5 mm or more. The clinical parameters, including PD,
... including PD, clinical attachment level (CAL), plaque index (PI), gingival index (GI), bleeding on probing (BOP), and radiographic examinations were recorded at baseline, 3 months and 6 months. The results showed that both treatment groups significantly improved with regard to clinical parameters (p<0.05); however, the between-group differences were mostly insignificant (p>0.05), although SRP+AP showed a greater PD reduction than SRP+PB (p<0.05) between baseline and 3 months. In conclusion, the adjunctive use of AP gel significantly reduces PD and significantly improves attachment level.