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Dynamics of telomere length and mitochondrial health in relation to combination antiretroviral therapy (cART) exposure : a cohort study of HIV/cART-exposed uninfected children and cell culture investigations
Combination antiretroviral therapy (cART) during pregnancy has considerably reduced the risk of mother-to-child HIV transmission and the number of cART-exposed HIV-exposed uninfected (HEU) children is increasing. With current treatment guidelines recommending the initiation of immediate, lifelong cART at HIV diagnosis, women conceive on therapy and HEU in utero cART exposure spans the entire gestation period. Many antiretrovirals (ARV) cross the placenta and could exert long-term effects ondoi:10.14288/1.0378964 fatcat:j6wrgb45w5ahplfu4wr2ewmrqe