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Exposure to environmental chemicals and drugs may have a negative effect on human health. A better understanding of the molecular mechanism of such compounds is needed to determine the risk. We present a high confidence human protein-protein association network built upon the integration of chemical toxicology and systems biology. This computational systems chemical biology model reveals uncharacterized connections between compounds and diseases, thus predicting which compounds may be riskdoi:10.1371/journal.pcbi.1000788 pmid:20502671 pmcid:PMC2873901 fatcat:kmspfh4hubdzhjdovcj26fqn5m