Phorbol esters isolated from Croton megalobotrys reverse HIV latency ex vivo

I. Tietjen, K. Richard, D. Williams, J. Rivera-Ortiz, Y. Cai, A. Pagliuzza, N. Chomont, R. Andersen, L. Montaner, K. Andrae-Marobela
2019 Journal of virus eradication  
44 No difference was found in HIV-DNA (P=0.620 and P=0.530) at T1 and T3 between APACHE and MODAT patients. At T1, 5/7 APACHE and 3/7 MODAT carried MRMs with a median IPP of 38.1 and 99.0, respectively. In APACHE pts, MRMs persisted during ATI in 2/7 (both with IPP >99.0%) and in 4/7 (median IPP=53.1) at plasma level and in PBMCs, respectively. Post-ATI, HIV-DNA MRMs were found in 3/7 pts (with IPP of 1.4%, 99.6%, 99.8%). Comparing preand post-ATI HIV-DNA sequences, MRMs with a T1IPP <80%
more » ... icantly decreased from pre-to post-ATI (IPP: 7.2 vs. 0; P=0.01), which occurred mainly in APOBEC-3G related MRMs. In MODAT pts, MRM prevalence did not change duringfollow-up, including MRMs with a T1IPP <80% (P=0.180). Conclusions: This proof of concept study confirms that ATI does not affect the value of post-ATI peripheral HIV-DNA, but suggests that ATI may be associated with rearrangement of peripheral archived MRMs and, in some cases, with their complete reversal. PP 5.7.11 Persistent HIV reservoir suppression by (-)-hopeaphenol, a plant-derived stilbenoid
doi:10.1016/s2055-6640(20)30191-6 fatcat:5ebmjiy6obb3hlvvedghcm3b24