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Phorbol esters isolated from Croton megalobotrys reverse HIV latency ex vivo
Journal of virus eradication
44 No difference was found in HIV-DNA (P=0.620 and P=0.530) at T1 and T3 between APACHE and MODAT patients. At T1, 5/7 APACHE and 3/7 MODAT carried MRMs with a median IPP of 38.1 and 99.0, respectively. In APACHE pts, MRMs persisted during ATI in 2/7 (both with IPP >99.0%) and in 4/7 (median IPP=53.1) at plasma level and in PBMCs, respectively. Post-ATI, HIV-DNA MRMs were found in 3/7 pts (with IPP of 1.4%, 99.6%, 99.8%). Comparing preand post-ATI HIV-DNA sequences, MRMs with a T1IPP <80%doi:10.1016/s2055-6640(20)30191-6 fatcat:5ebmjiy6obb3hlvvedghcm3b24