Synthetic and biological experiments from Nε-acetyl-lysine derivatives with zinc binding groups as novel HDAC inhibitors

Fang Wang, Chun Wang, Jie Wang, Yefang Zou, Xiaoxue Chen, Ting Liu, Yan Li, Yonglong Zhao, Yongjun Li, Bin He
2019 Figshare  
HDAC inhibitors have been developed very rapidly in clinical trials and even in approvals for treating several cancers. However, there are few reported HDAC inhibitors designed from Nε-acetyl lysine. In current study, we raised a novel design, which is about Nε-acetyl lysine derivatives containing amide acetyl groups with the hybridization of ZBG groups as novel HDAC inhibitors.
doi:10.6084/m9.figshare.8152961 fatcat:n2nl2zmeorh7lnojbo23kp5wei