LE JOURNAL CANADIEN DES SCIENCES NEUROLOGIQUES development, and Section 2 examines the use of animal experiments to study the neurobiological basis for pain with special attention to the trigeminovascular system. Section 3 deals with in vitro models of migraine, and discusses the molecular pharmacology of the 5HT ]D receptor system and mechanisms related to neuropeptides and amines. Section 4 describes in vivo animal models of migraines, and discusses models based on neurogenic and vascular

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... anisms, with articles dealing with cranial arteriovenous shunting, neurogenic inflammation, cortical spreading depression and other mechanisms. Section 5 deals with human models of vascular headache, such as nitroglycerin-induced headache, as well as others. Section 6 deals with models of non-migrainous headache, including tension-type and cluster headache. Some of these models are largely theoretical. This book includes contributions by many well-known researchers in the field of headache, and is an up-to-date summary of the field. Despite the editing, the various contributions differ significantly in quality and importance. Although many neurologists would be interested in the cerebrovascular pain pathways of relevance to migraine, fewer might be interested in a new methodology to study muscle fatigue in normal and headache patients, or in the effects of peppermint and eucalyptus oral preparations on neurophysiological and experimental algesimetric headache parameters. Many of the contributions to this volume would also benefit from a short succinct summary. In summary, this volume will be of interest to the headache specialist, and perhaps the neurologist with a major interest in headache. Most of it will be too specialized to be of interest to the average neurologist. However, it is a valuable reference, and selected articles will be of interest to all those wrestling with the major new developments in serotonin receptor research and the pharmacology of migraine treatment.