Localization of a Type 1 Diabetes Locus in the IL2RA/CD25 Region by Use of Tag Single-Nucleotide Polymorphisms

Adrian Vella, Jason D. Cooper, Christopher E. Lowe, Neil Walker, Sarah Nutland, Barry Widmer, Richard Jones, Susan M. Ring, Wendy McArdle, Marcus E. Pembrey, David P. Strachan, David B. Dunger (+3 others)
2005 American Journal of Human Genetics  
As part of an ongoing search for genes associated with type 1 diabetes (T1D), a common autoimmune disease, we tested the biological candidate gene IL2RA (CD25), which encodes a subunit (IL-2Ra) of the high-affinity interleukin-2 (IL-2) receptor complex. We employed a tag single-nucleotide polymorphism (tag SNP) approach in large T1D sample collections consisting of 7,457 cases and controls and 725 multiplex families. Tag SNPs were analyzed using a multilocus test to provide a regional test for
more » ... ssociation. We found strong statistical evidence in the casecontrol collection ( ) for a T1D locus in the CD25 region of chromosome 10p15 and replicated the 58 P p 6.5 # 10 association in the family collection ( ; combined ). These results illustrate the utility 53 510 P p 7.3 # 10 P p 1.3 # 10 of tag SNPs in a chromosome-regional test of disease association and justify future fine mapping of the causal variant in the region.
doi:10.1086/429843 pmid:15776395 pmcid:PMC1199367 fatcat:e2uafdvazjhdjd5xbnjtxxrvuq