Effects of ninadab on NF- κB expression in lung tissue and PCⅢ level in bronchoalveolar lavage fluid induced by lipopolysaccharideinduced ARDS in rats

Yang Li-Xia, Qin-Yao Jia, Li Jiang
2018 Journal of Hainan Medical University  
Objective: To observe effects of ninadab on NF-κB expression in lung tissue and PCⅢ level in bronchoalveolar lavage fluid induced by lipopolysaccharide-induced ARDS in rats. Methods: Forty healthy SD rats were randomly divided into control group, group A, group B and group C, with 10 in each group. Rats in group A, group B and group C were successful in modeling. In control group, rats in group A were injected with saline only. Rats in group B were treated with nisinib at 7 days and rats in
more » ... ays and rats in group C were treated with nisinib at 14 days. The expression of NF-κB in lung tissue, the level of β-EP in plasma and the level of PCⅢ in bronchoalveolar perfusion fluid. Results: There were significant differences in the expression of NF-κB positive cells and plasma β-EP among groups. Compared with the control group, the expression of NF-κB positive cells and plasma β-EP in group A, group B and group C were significantly higher than those in control group, Compared with group A, the expression of NF-κB positive cells and plasma β-EP in group B and group C were significantly lower than those in group A. Compared with group B, the expression of NF-κB positive cells and plasma β-EP in group C were significantly higher than those in group B. There was a significant difference between the 4 groups on the 7th, 14th and 28th days. Compared with the control group, PCⅢ levels in the 7th, 14th and 28th days in group A, group B and group C were significantly higher. Compared with group A, group B, group C, the content of PCⅢ on the 7th day, the 14th day and the 28th day in group C was significantly higher. Conclusion: Nidanib on lipopolysaccharide-induced ARDS rats have a good protective effect, and its mechanism may be related to the reduction of NF-κB expression in bronchoalveolar perfusion solution PCⅢ level.
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