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Effects of daptomycin in combination with other antimicrobial agents: a review of in vitro and animal model studies
Journal of Antimicrobial Chemotherapy
This review summarizes the in vitro and animal model data available on antibiotic combinations with daptomycin. The majority of studies focus on the clinically relevant combinations of daptomycin with rifampicin or with gentamicin. These studies demonstrate that daptomycin does not adversely affect the activity of other antimicrobial agents that may be administered concomitantly. Overall, additive or indifferent effects with daptomycin combinations were observed; however, synergy was observeddoi:10.1093/jac/dkp346 pmid:19825818 fatcat:n4s6ljc75fahzfm3koxdmfw3jq