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A young woman with slowly progressive muscular weakness and atrophy localized in both thighs is reported. Laboratory, electromyographic and histological findings suggested that the patient suffered from chronic myositis with a background of autoimmune disorder. Quadriceps myositis is a rare condition. The previously reported cases of this disease in the literature are reviewed. (Internal Medicine 31: 926-929, 1992)doi:10.2169/internalmedicine.31.926 fatcat:6by5topbardazohb5seszt5ppm