Surgical site infections have been a major problem, because of the emergence of drug resistant bacteria, in particular B-lactamase producing bacteria. Extended spectrum beta lactamase producing gram negative organisms pose a great challenge in treatment of SSI present study is aimed at determining multiple drug resistance in gram negative bacteria & to find out ESBL producers, in correlation with treatment outcome. A total of 120 wound infected cases were studied. Staphylococcus aureus was

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... minant bacterium-20.Among gram negative bacteria, Pseudomonas species is predominant(14) followed by Escherichia coli(13), Klebsiella species (12) , Proteus(9) Citrobacter(4) Providencia(2) & Acinetobacter species(2). Out of 56 gramnegative bacteria isolated, 20 were identified as ESBL producers, which was statistically significant. Delay in wound healing correlated with infection by ESBL producers, which alarms the need of abstinence from antibiotic abuse.