1918 Journal of the American Medical Association (JAMA)  
were at their height. It is important to keep the proagglutinoid zone in mind, lest through an insufficiently high dilution a tube in the pro-agglutinoid zone should be read as a wholly negative result. While Zinsser, basing his opinion on the work of Bechtold6 and that of Neisser and Friedman,7 considers the assumption of pro-agglutinoids unnecessary, their existence would serve to make clearer some of the phenomena noticed. That the pro-agglutinoids not only completely inhibit the
more » ... n in the lower dilutions but partially inhibit it in the higher dilutions is possible. This supposition is borne out by the fact that when the titer of a serum comes down, the pro-agglutinoid zone precedes it, and with the total disappearance of this zone, a secondary rise on the agglutinin titer appears, which is difficult to account for in any other fashion. CONCLUSIONS 1. Definite agglutinins for all three organisms are developed after the use of Army vaccine. They are equal after alternating doses and triple, vaccine, the methods are equally effective, and the time-saving element in the latter is obvious. 2. Previous vaccination has the effect of repressing agglutinins for the specific organism. 3. Fluctuations in agglutinin content occur after vaccination, in normal cases, and are of little diagnostic value in cases of fever. 4. There is no relation between the systemic and the local reaction, after vaccination, and the units of agglutinins produced.
doi:10.1001/jama.1918.26010250005006a fatcat:haybxmvjmzeobhf6xxswu3n6pu