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Highly efficient mechanisms regulate intracellular calcium (Ca 2+ ) levels. The recent discovery of new components linking intracellular Ca 2+ stores to plasma membrane Ca 2+ entry channels has brought new insight into the understanding of Ca 2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca 2+ sensor essential for Ca 2+ store depletion-triggered Ca 2+ influx. Orai1 was recognized as being an essential component for the Ca 2+ release-activated Ca 2+ (CRAC) channel.doi:10.1590/s0100-879x2011007500133 pmid:22002090 fatcat:zybpdqtoi5gvpnnjhss7vkbpmu