STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg

F.R. Giachini, V.V. Lima, J.L. Hannan, F.S. Carneiro, R.C. Webb, R.C. Tostes
2011 Brazilian Journal of Medical and Biological Research  
Highly efficient mechanisms regulate intracellular calcium (Ca 2+ ) levels. The recent discovery of new components linking intracellular Ca 2+ stores to plasma membrane Ca 2+ entry channels has brought new insight into the understanding of Ca 2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca 2+ sensor essential for Ca 2+ store depletion-triggered Ca 2+ influx. Orai1 was recognized as being an essential component for the Ca 2+ release-activated Ca 2+ (CRAC) channel.
more » ... gether, these proteins participate in store-operated Ca 2+ channel function. Defective regulation of intracellular Ca 2+ is a hallmark of several diseases. In this review, we focus on Ca 2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/ Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.
doi:10.1590/s0100-879x2011007500133 pmid:22002090 fatcat:zybpdqtoi5gvpnnjhss7vkbpmu