To investigate the influence of different wheelchair tilt-in-space and reclining angles on pressure force and shear force in the gluteal region. We included 12 healthy subjects in this study. To measure the amount of pressure force and shear force applied to the gluteal region while sitting, a force plate was used to measure the floor reaction force. Protocols for six wheelchair tilt-in-space and reclining angles, including 0°reclining and 0°tilt-in-space (r0t0), 10°reclining (r10) and

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... ing (r20), and 10°tilt-in-space (t 10) and 20°tilt-in-space (t20), were randomly assigned to the 12 subjects. The pressure force in the r10, r20, r30, and t20 conditions was significantly lower than that in the r0t0 condition. The pressure force in the r20 and r30 conditions was significantly lower than that in the t20 condition. The anterior component of the shear force in the r0t0 condition was significantly lower than that in the r10, r20, and r30 conditions and significantly higher than that in the t10 and t20 conditions. The posterior component of the shear force in the t20 condition was significantly higher than that in the t10 condition (p < 0.05). The results of the present study indicate that reclining angles decrease the pressure force and 10°tilt-in-space angles decrease the shear force in the gluteal region while sitting on a wheelchair.