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Representing roles, i.e. functions of proteins, sequences and structures, is the cornerstone of knowledge representation in functional genomics. The objective of this study is to investigate representation of roles as functional categories or associative relations. We focus on GeneOntology (GO) and the UMLS and take examples from iron metabolism. The terms corresponding to the main proteins involved in iron metabolism were mapped to GO (including the annotations) and the UMLS. Thepmid:12463792 pmcid:PMC2244301 fatcat:lp5zv3jpivbnpgptxgj4eutcre