Representation of roles in biomedical ontologies: a case study in functional genomics

Anita Burgun, Olivier Bodenreider, Franck Le Duff, Fouzia Moussouni, Olivier Loreal
2002 Proceedings. AMIA Symposium  
Representing roles, i.e. functions of proteins, sequences and structures, is the cornerstone of knowledge representation in functional genomics. The objective of this study is to investigate representation of roles as functional categories or associative relations. We focus on GeneOntology (GO) and the UMLS and take examples from iron metabolism. The terms corresponding to the main proteins involved in iron metabolism were mapped to GO (including the annotations) and the UMLS. The
more » ... of their biological roles was then analyzed. Functional aspects are represented in both GO and the UMLS. However, the granularity may not be appropriate. Advantages and limits of functional categories and associative relations are discussed.
pmid:12463792 pmcid:PMC2244301 fatcat:lp5zv3jpivbnpgptxgj4eutcre