Ubiquitin-Dependent Proteolysis in Neurons

Lars Klimaschewski
2003 Physiology  
Various studies identified the ubiquitin-proteasome system as the prime suspect in causing neurodegenerative diseases. The present review summarizes our current knowledge about the expression, regulation, and functions of this major protein degradation pathway in the brain, with particular reference to the pathogenesis of associated neurological diseases. by 10.220.32.246 on August 9, 2017 http://physiologyonline.physiology.org/ Downloaded from News Physiol Sci • Vol. 18 • February 2003 •
more » ... bruary 2003 • www.nips.org 32 FIGURE 2. Dissociated sympathetic neurons treated with the proteasome inhibitor lactacystin (10 PM) for 24 h. Note the phase-dark cytoplasmic inclusion bodies (arrows) in the large, viable neurons with intact nuclei (as revealed by Hoechst staining). Degenerated neurons exhibiting apoptotic nuclei do not contain inclusions. Bar = 15 Pm.
doi:10.1152/nips.01408.2002 pmid:12531929 fatcat:yuggsmxacbcwfnvyrsq65gldqq