Genome-scale dynamic modeling of the competition between Rhodoferax and Geobacter in anoxic subsurface environments

Kai Zhuang, Mounir Izallalen, Paula Mouser, Hanno Richter, Carla Risso, Radhakrishnan Mahadevan, Derek R Lovley
2010 The ISME Journal  
In situ bioremediation by Fe(III) reducers is a strategy for clean-up of ground water through reductive immobilization. The dynamics of the community involved is complex and needs to be understood better for improving the bioremediation. Here, we have created a dynamic genome-scale metabolic model of Geobacter sulfurreducens and Rhodoferax ferrireducens, the two primary iron-reducers in subsurface environments, in order to understand the community competition prior to and during
more » ... ation. The simulation results suggest that the community competition is modulated by two factors: the ability of G. sulfurreducens to fix nitrogen under ammonium limitation, and a rate vs. yield trade-off between these two organisms. This model will be an important tool for the analyses of more complex microbial communities and the design of effective uranium-bioremediation strategies.
doi:10.1038/ismej.2010.117 pmid:20668487 pmcid:PMC3105697 fatcat:l5scltqiyrflnnytpes2tp5iwa