We evaluated the effects of a novel calcium antagonist, manidipine, on albuminuria in rats with passive Heymann nephritis (PHN). Treatment with 0.05% manidipine significantly reduced urinary albumin excretion (62.1•}7.5 vs. 46.9•}8.5 mg/urinary ereatinine excretion mg, P<0.05) and attenuated lipid peroxidation of the renal cortices (0.97•}0.08 vs. 0.84•}0.11 nM MDA/mg protein, P<0.05) on day 14 in PHN. Manidipine affected neither the light microscopic, immunofluorescent nor electron microscopic

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... findings. These results indicate that manidipine reduced proteinuria in rats with PHN, and that its antiproteinuric effect was associated with the reduction of lipid peroxidation.