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Ketoconazole revisited: a preoperative or postoperative treatment in Cushing's disease
European Journal of Endocrinology
ContextAlthough transsphenoidal surgery remains the first-line treatment in Cushing's disease (CD), recurrence is observed in about 20% of cases. Adjunctive treatments each have specific drawbacks. Despite its inhibitory effects on steroidogenesis, the antifungal drug ketoconazole was only evaluated in series with few patients and/or short-term follow-up.ObjectiveAnalysis of long-term hormonal effects and tolerance of ketoconazole in CD.DesignA total of 38 patients were retrospectively studieddoi:10.1530/eje-07-0514 pmid:18166822 fatcat:c3aduy67ofd5dk4tyhdrqlfvym