Epidemiologic studies demonstrated that fertility begins to decline while women reached age 25. This is due to a decline in oocyte quality such as aneuploidy rather than merely decreasing oocyte number. The decline in oocyte quality becomes clinically relevant for women from their mid-30s. The prevalence of infertility increases from 1% at age 25 to 55% at age 45. While 75% of women attempting conception at age 30 conceive within 12 months, by age 40 this has declined to 44%. Further, 20% of

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... en who conceive at age 35 will have a spontaneous abortion. The monthly fecundity resulting in live-birth rate among women aged 30, 35 and 40 year is 17%, 12% and 5% respectively. 1 Indones J 58 Hestiantoro Obstet Gynecol |