FASUDIL HYDROCHLORIDE EFFECTS ON EAAT2 AND ROCK2 PROTEIN EXPRESSIONS IN RAT MODEL OF NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY

NdefiA ntimaYadiswaRobert, WangXian He, ZhangYa Li, ZhuZhang Long, Raihanx RaihanKibria, Nalika Robai, Indranil Ghosh
2017 International Journal of Advanced Research  
Objective: To evaluate fasudil effects on EAAT2 and ROCK2 protein expressions in rat model of neonatal hypoxic-ischemic brain damage (HIBD). Methodology: 144 Seven-day-old Wistar rats were randomly divided into sham, HIBD, and fasudil groups. Fasudil group were injected intraperitoneally with that compound. Rat brains at 2, 6,12, 24, 48 and 72 h after HIBD were collected to determine histopathological damage and the expression levels of EAAT2 and ROCK2 proteins selected as the average optical
more » ... nsity (AOD).Results were reported as average (x)standard deviation (SD), and single-factor analysis of variance (ANOVA) was performed between the multiple groups. A value of P <0.05 was considered statistically significant.
doi:10.21474/ijar01/3997 fatcat:vbugiwtcz5hwncibhimsggcsiu