Synthesis, Characterization and Biological Evaluation of Some 1,3,4-oxadiazole Incorporated Coumarin Derivatives as Antifungal Agents

Muhammad Abul Kashem Liton, Md. Sajid Hasan, Sabrina Helen, Mukta Das, Md. Shalauddin
2022 Zenodo  
Coumarins are the family of benzopyrones, in which benzene ring amalgamated with the pyrone ring. Their versatile oxygen-containing heterocyclic structure and physicochemical characteristics are responsible to attract great attention from medicinal chemists and pharmacologists and for being a privileged scaffold in medicinal chemistry. In this study, 1, 3, 4 -oxadiazole incorporated a series of new coumarin derivatives have been synthesized. Structures of the newly synthesized compounds were
more » ... ablished on the basis of FT-IR, 1H NMR spectroscopic techniques and elemental analysis. The synthesized compounds were screened for their in vitro antifungal activity against five pathogenic fungal strains: Aspergillus niger, Penicillium notatum, Saccharomyces cerevisiae, Penicillium chrysogenum and Neurospora crassa by disk-diffusion method. All the compounds were found to have significant antifungal activity against all the fungal strains. Keywords: Coumarins, 1,3,4-oxadiazole, Antifungal Activity.
doi:10.5281/zenodo.6659389 fatcat:656r72ier5fuxoishgm4zoius4