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Anxiogenic-like effect of acute and chronic fluoxetine on rats tested on the elevated plus-maze
1999
Brazilian Journal of Medical and Biological Research
The selective serotonin reuptake inhibitor fluoxetine (FLX) is widely prescribed for depression and anxiety-related disorders. On the other hand, enhanced serotonergic transmission is known to be classically related to anxiety. In this study, the effects of acute (5.0 mg/kg) and chronic (5.0 mg/kg, 22 days) FLX were investigated in both fooddeprived and non-deprived rats tested in the elevated plus-maze. Significant main effects of the three factors (drug, food condition and administration
doi:10.1590/s0100-879x1999000300014
pmid:10347793
fatcat:hwqyumocbfcrfknannvsgadtg4