Schusterova I, 1th Department of Cardiology, East Slovak Institute of Cardiovascular Diseases, Kosice, Slovakia., Banovcinova A, Takacova J, Takac L, Artemiou P, Leenen FHH, Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, P.J. Safarik University in Kosice, Slovakia., University of Veterinary Medicine and Pharmacy, Kosice, Slovakia., University of Veterinary Medicine and Pharmacy, Kosice, Slovakia., The National Institute of Cardiovascular Disease, Bratislava, Slovakia., Hypertension Unit, University of Ottawa Heart Institute, Ottawa, Canada (retired).
2019 International Journal of Advanced Research  
High serum uric acid (UA) levels appear to contribute to an increase in blood pressure (BP) in obese adolescents and may amplify the cardiac volume overload effects of obesity with pressure overload. Association between UA and ejection fraction (EF) is still controversial. Some studies showed negatively correlations, others did not found any correlation. So far, no data have been published regarding the influence of UA levels on structural and functional changes of the LV in children with
more » ... y. Objective: The aim of our study was to assess the influence of UA levels on LV structure and function in overweight/obese children. Study groups and methods: In 25 (mean age 13.0 ± 2.3) overweight/obese subjects and 24 lean controls, BP, fasting plasma glucose, insulin, and UA were measured. LV structural and functional parameters were measured by echocardiography. Results: In overweight/obese children UA correlates with LV diastolic volumes and LV systolic function but not with LVM whereas in children without obesity UA correlates with LVM and LV diastolic function. Conclusion: The present study demonstrates a positive correlation of UA with EF and left atrium and LV volume in volume overload due to obesity in children. These conclusions require further investigation. Copy Right, IJAR, 2019,. All rights reserved. ...................................................................................................................... Introduction:- Obesity is associated with a shortened life expectancy mainly because of increased risk for cardiovascular (CV) disease. Uric acid (UA) levels have been shown to be a good marker for metabolically unhealthy obesity i.e. those with features of metabolic syndrome and elevated CV risk factors in adolescence and adulthood (1). High UA levels are a risk factor for hypertension in adults (2). Several studies have assessed the relationship between UA levels and LV mass (LVM) in adults with hypertension (3,4). The development of LV hypertrophy (LVH) in hypertensive adults with high UA levels can at least partially explain the elevated CV risk observed in
doi:10.21474/ijar01/9843 fatcat:u6zi7wa2rre6hnmrnlkq4d6mke