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BACKGROUND: Hypothalamic amenorrhoea (HA) is a syndrome associated with infertility and osteopenia in reproductive-age women. METHODS: To understand better the natural history of this disorder, 28 women participated in a retrospective, questionnaire-based analysis to elucidate factors associated with spontaneous recovery. RESULTS: 54% of subjects developed HA related to an eating disorder, 21% related to stress ⍨ weight loss, and 25% without obvious contributing factors (idiopathic). HAdoi:10.1093/humrep/16.10.2198 pmid:11574516 fatcat:x2ad5ie5tvartj32qr2lydqrwu