Prognostische Wertigkeit inflammatorischer Marker und natriuretischer Peptide bei Patienten mit akutem Myokardinfarkt
This study compares different risk markers in 70 consecutive patients with acute myocardial infarction treated with primary PCI in our hospital from March 2000 to May 2001. The goal of the study was to compare the short term prognostic information (28 day mortality) of NT-pro-BNP with other markers. At predefined times ANP-, NT-proBNP-, BNP-, IL-6- and CRP-plasma-levels were measured during hospitalization and their short term prognostic value was compared with the APACHE-II-Score. The patients
... Score. The patients were dichotomized using the 1. , 2. and 3. tertile, because there were no differences in outcome in patients assigned to the 1. and 2. tertile of N-BNP at 28 days follow up, the groups were merged into 1 group for survival statistical analysis. Multivariate analysis showed that an increased level of NT-pro-BNP was independently associated with short term mortality. The superiority of NT-pro-BNP as a prognostic marker compared with BNP is probably due to quicker increase of plasma levels after myocardial infarction, longer plasma half-life and stronger correlation with age and kidney function. We also found the APACHE-II-Score to be an excellent prognostic marker for short term mortality in our patient, as was previously shown in other studies.