A new series of 4-phenyl-1,8-naphthyridine derivative, substituted in position 6 and 7 were prepared and tested for their inhibitory effects on platelet aggregation by ADP, the most promising agent among them was2-(4'-methoxybenzylamine)-6-amino-7-(piperidin-1-yl)-4-phenyl-1,8-naphthyridine designated as14. The specificity of the inhibitory effects of 14 is presented by cycloalkyl amino moiety of the agent. Moreover, platelet aggregation induced by agonists other than ADP e.g., arachidonic

more »

... and collagen, was inhibited completely by compound 14. The analogues designated 12 and 13 showed a higher activity than that of 8-11 derivatives. Compounds 13 and 14 increased cAMP levels and significantly inhibited platelet aggregation.