Continuous flow synthesis of L-menthyl glyoxylate monohydrate: an important intermediate in the manufacture of ARVs

Paul Watts, McQuillan Moyo, Cloudius Ray Sagandira, Bert Maes
2020 ARKIVOC  
L-Menthyl glyoxylate monohydrate (LMGH) is an important pharmaceutical intermediate in the synthesis of lamivudine and emtricitabine. Conventionally, the synthesis of this intermediate has been done in batch. The present work demonstrates various continuous flow synthetic procedures towards LMGH in up to 78% yield and 92% selectivity with residence time of five minutes or less.
doi:10.24820/ark.5550190.p011.226 fatcat:zy7mvfbpurdxfeytog665hmo2i