Smoking and tobacco chewing forms a major killer of this era. It changes lipid profile which increases risk of coronary heart disease. Smoking and tobacco chewing is associated with an increased risk of atherosclerotic vascular disease. ABI is reliable indicator of high coronary risk and is significantly related to disease of coronary artery disease. Aim: The aim of study is to study lipid profile in smokers and tobacco chewers and the correlation of their habit with coronary artery disease.

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... erial and Method: Total 125 individuals who admitted in intensive care unit at Mallareddy hospital from 2018-2019 were taken for the study out of which 100 were patients and 25 were control. The study was conducted in 5 groups of both sex from age (20-70 years) with BMI<27.each group contain 25 subjects. The serum lipid profile level were calculated after overnight fasting and ankle brachial index was calculated and correlation of each group with ABI with CAD grading was done. Result: smokers and tobacco chewers have dyslipidemic changes and increase incidence of CAD than non-smokers. As the no of years of habit increased the clinical and CAD grading of ABI increased. Conclusion: Both tobacco chewers and smokers (cigarette and bidi smokers) are at increased risk of coronary artery disease as compared to non-tobacco consuming and non-smoking population. Our research indicated that ABI could be a useful method in assessing both the atherosclerotic risk factors and the degree of coronary involvement.