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Genome-scale metabolic models (GEMs) have become a popular tool for systems biology, and they have been used in many fields such as industrial biotechnology and systems medicine. Since more and more studies are being conducted using GEMs, they have recently received considerable attention. In this review, we introduce the basic concept of GEMs and provide an overview of their applications in biotechnology, systems medicine, and some other fields. In addition, we describe the general principledoi:10.3389/fphys.2015.00413 pmid:26779040 pmcid:PMC4703781 fatcat:j7ggvr7ntrgj7lqmn5kiwzq354