Gray Matter Volume Decrease Distinguishes Schizophrenia From Bipolar Offspring During Childhood and Adolescence

Gisela Sugranyes, Elena de la Serna, Soledad Romero, Vanessa Sanchez-Gistau, Anna Calvo, Dolores Moreno, Inmaculada Baeza, Covadonga M. Diaz-Caneja, Teresa Sanchez-Gutierrez, Joost Janssen, Nuria Bargallo, Josefina Castro-Fornieles
2015 Journal of the American Academy of Child and Adolescent Psychiatry  
Objective: There is increasing support toward the notion that schizophrenia and bipolar disorder share neurodevelopmental underpinnings, although areas of divergence remain. We set out to examine gray matter volume characteristics of child and adolescent offspring of patients with schizophrenia or bipolar disorder comparatively. Conclusion: This first comparative study between offspring of patients with schizophrenia and bipolar disorder suggests that gray matter volume reduction in childhood
more » ... d adolescence may be specific to offspring of patients with schizophrenia; this may index a greater neurodevelopmental impact of risk for schizophrenia relative to bipolar disorder during youth.
doi:10.1016/j.jaac.2015.05.003 pmid:26210337 fatcat:anifcsqlcbfplhquaaipna6jry