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The prognostic value of Ki-67, p53 and ER immunohistochemical labelling and flow-cytometnc S-phase fraction and ploidy was evaluated in 212 pTlNOM0 breast carcinomas. The mean follow-up time was 8.3 years. Patients with breast carcinomas with high Ki-67 expression ( 2 10%) had a less favourable disease-free survival than those with low Ki-67 expression ( < 10%) (p = 0.008). A positive p53 staining and high SPF were associated with a less favourable disease-free survival although it did notdoi:10.3109/02841869709001282 pmid:9247096 fatcat:jzs6aex3o5arlpdnphvnp6pyha