Ki-67, p53, Er-Receptors, Ploidy and S-Phase as Prognostic Factors in T1 Node Negative Breast Cancer

Mikael Railo, Johan Lundin, Caj Haglund, Karl von Smitten, Kristina von Boguslawsky, Stig Nordling
1997 Acta Oncologica  
The prognostic value of Ki-67, p53 and ER immunohistochemical labelling and flow-cytometnc S-phase fraction and ploidy was evaluated in 212 pTlNOM0 breast carcinomas. The mean follow-up time was 8.3 years. Patients with breast carcinomas with high Ki-67 expression ( 2 10%) had a less favourable disease-free survival than those with low Ki-67 expression ( < 10%) (p = 0.008). A positive p53 staining and high SPF were associated with a less favourable disease-free survival although it did not
more » ... ugh it did not reach statistical significance. The subset of patients with ER negative, Ki-67 2 10% and p53 220'1/0 tumours, had a shorter disease-free survival compared with that of all the other patients (p = 0.03). We conclude that the potential value of Ki-67 labelling for prognostic evaluation of TlNOMO breast carcinoma is good.
doi:10.3109/02841869709001282 pmid:9247096 fatcat:jzs6aex3o5arlpdnphvnp6pyha