A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf
.
Model-order reduction of ion channel dynamics using approximate bisimulation
2015
Theoretical Computer Science
We show that in the context of the Iyer et al. (IMW) 67-variable cardiac myocycte model, it is possible to replace the detailed 13-state probabilistic model of the sodium channel dynamics with a much simpler Hodgkin-Huxley (HH)-like two-state model, while only incurring a bounded approximation error. We then extend our technique to the 10-state model of the fast recovering calcium-independent potassium channel. The basis of our results is the construction of an approximate bisimulation between
doi:10.1016/j.tcs.2014.03.018
fatcat:yot5xlpl7raszohwr6xthgfxky