Structure-based design of selective high-affinity telomeric quadruplex-binding ligands

Caterina Maria Lombardo, Iria Sánchez Martínez, Shozeb Haider, Valérie Gabelica, Edwin De Pauw, John E. Moses, Stephen Neidle
2010 Chemical Communications  
A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.
doi:10.1039/c0cc02917c pmid:21038041 fatcat:hxktur2ztbd23izf2v3jtvysey