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A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.doi:10.1039/c0cc02917c pmid:21038041 fatcat:hxktur2ztbd23izf2v3jtvysey