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Identification of Physical Interaction in Binary Systems of Acyclovir – Succinic Acid

Agnes Nuniek Winanta, Dwi Setyawan, Siswandono
2017 JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA  

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Acyclovir, a guanosine analogue antiviral drug with low solubility of water. Due to its poor solubility and permeability, causes low oral bioavailability. Objective: The aim of this research is to investigate the physical interaction in binary systems acyclovir-succinic acid (AS). Methods: The msystem was prepared by solvent evaporation method. Results: Thermogram Differential Scanning Calorimetry showed endothermic peaks at 172.68oC (ethanol) and 171.84oC (methanol). The Powder X-Ray
more » ... n (PXRD) pattern of AS was different from pure component and physical mixtures. Furthermore, physical characterization showed the binary system of AS have unique crystal habit by polarization microscope. Conclusion: New crystalline phase is formed from the interaction between acyclovir and succinic acid by solvent evaporation method using ethanol and methanol.
doi:10.20473/jfiki.v3i1.4091 fatcat:2y36ztsblnh7dgttetlbush6ti
DOAJ
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Agnes Nuniek Winanta, Dwi Setyawan, Siswandono. "Identification of Physical Interaction in Binary Systems of Acyclovir – Succinic Acid." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 3.1 (2017) 27