Interaction between amorolfine and voriconazole against Fusarium species [post]

Pin Liang, Jiquan Song, Qin Liu
2020 unpublished
Background: Fusarium species are environmentally ubiquitous fungi capable of causing diverse superficial, locally invasive, or disseminated infections, making them important pathogens. Compared with antibacterial drugs, the types of antifungal drugs are still limited, and the adverse reactions are significant. Therefore, novel treatments against Fusarium spp. are an urgent need.Results: Here we investigated the interaction of amorolfine combined with voriconazole on Fusarium spp. Our study
more » ... spp. Our study demonstrated that amorolfine in combination with voriconazole could inhibited the Fusarium spp. significantly. Galleria mellonella was also used as a model to show the interaction of the two-drug combination in vivo against Fusarium spp.; larval survival rates were significantly higher after treatment with the amorolfine-voriconazole combination compared to the monotherapy group.Conclusions: This study is the first to demonstrate that voriconazole combined with amorolfine has a synergistic effect against Fusarium spp. infection and may be an effective method for antifungal therapy.
doi:10.21203/rs.3.rs-53804/v1 fatcat:q27kt7pddva5rkbdieen6jrij4