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Action potential initiation, propagation, and cortical invasion in the hyperdirect pathway during subthalamic deep brain stimulation
2018
Brain Stimulation
BACKGROUND-High frequency (~130 Hz) deep brain stimulation (DBS) of the subthalamic region is an established clinical therapy for the treatment of late stage Parkinson's disease (PD). Direct modulation of the hyperdirect pathway, defined as cortical layer V pyramidal neurons that send an axon collateral to the subthalamic nucleus (STN), has emerged as a possible component of the therapeutic mechanisms. However, numerous questions remain to be addressed on the basic biophysics of hyperdirect
doi:10.1016/j.brs.2018.05.008
pmid:29779963
pmcid:PMC6109410
fatcat:opzdgvehg5artehw5qhymh5fx4