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Inhaled iloprost for the treatment of pulmonary hypertension
European Respiratory Review
Prostacyclin and its analogues (prostanoids) are potent vasodilators, and exhibit antithrombotic, antiproliferative and anti-inflammatory properties. Pulmonary arterial hypertension (PAH) is characterised by vasoconstriction, thrombosis and proliferation, and is associated with reduced synthesis of endogenous prostacyclin. This provides a strong rationale for the use of prostanoids to treat PAH, a concept that is now supported by more than two decades of clinical research and experience.doi:10.1183/09059180.00011111 pmid:20956120 fatcat:xhcmqsbc7fchln2rqewguweg3y