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Multidrug-resistant Acinetobacter baumannii are increasingly becoming problematic to the healthcare system globally due to limited effective antibiotics. This thesis investigated the potential of repositioning non-antibiotic drugs for use in combination with polymyxin B to enhance the bacterial killing of this last-line antibiotic against these pathogens and prevent the emergence of polymyxin resistance. The in vitro and in vivo studies identified numerous promising non-antibiotic candidatesdoi:10.4225/03/5aca9a0b220ac fatcat:m267way5k5cn3owyldp3qfvtne