Treatment of multidrug-resistant Acinetobacter baumannii with novel combinations of polymyxin B and other non-antibiotic drugs

THIEN BON TRAN
2018
Multidrug-resistant Acinetobacter baumannii are increasingly becoming problematic to the healthcare system globally due to limited effective antibiotics. This thesis investigated the potential of repositioning non-antibiotic drugs for use in combination with polymyxin B to enhance the bacterial killing of this last-line antibiotic against these pathogens and prevent the emergence of polymyxin resistance. The in vitro and in vivo studies identified numerous promising non-antibiotic candidates
more » ... h synergistic antimicrobial activity against multiple Gram-negative bacteria including A. baumannii. The metabolomic studies revealed potential bacterial killing mechanisms of a novel combination and transcriptomic studies discovered numerous potential targets for future repositioning of non-antibiotic drugs.
doi:10.4225/03/5aca9a0b220ac fatcat:m267way5k5cn3owyldp3qfvtne