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Synthesis of Water Soluble Analogs of Arylsulfonylimidazolidinone (JSH-2282)
2013
Bulletin of the Korean Chemical Society (Print)
Preserved Fulltext
To improve the water solubility of arylsulfonylimidazolidinone (JSH-2282), a potent anti-cancer agent, two urea derivatives, sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)phenyl)ureido)succinate (2a) and sodium (S)-2-(3-(4-(5-((S)-2-oxo-4-phenylimidazolidin-1-ylsulfonyl)indoline-1-carbonyl)phenyl)ureido)pentanedioate (2b), were synthesized and studied for solubility and anti-cancer activity.
doi:10.5012/bkcs.2013.34.7.2011
fatcat:sg4zlfbf6vedxe4xwebwtru5ry