High efficacy of therapeutic equine hyperimmune antibodies against SARS CoV-2 variants of concern [article]

Andres Moreira-Soto, Mauricio Arguedas, Hebleen Brenes, Willem Buján, Eugenia Corrales-Aguilar, Cecilia Díaz, Ann Echeverri, Marietta Flores-Díaz, Aarón Gómez, Andrés Hernández, María Herrera, Guillermo León (+19 others)
2021 bioRxiv   pre-print
SARS-CoV-2 variants of concern (VoC) show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies. We tested therapeutic equine polyclonal antibodies (pAbs) against four VoC (alpha, beta, epsilon and gamma). We show that equine pAbs efficiently neutralize VoC, suggesting they are an effective, broad coverage, low-cost and a scalable COVID-19 treatment.
doi:10.1101/2021.06.12.448080 fatcat:yhbbbnbxrnhmjoynruewx7ut5y