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Functional Pangenome Analysis Shows Key Features of E Protein Are Preserved in SARS and SARS-CoV-2
2020
Frontiers in Cellular and Infection Microbiology
The spread of the novel coronavirus (SARS-CoV-2) has triggered a global emergency, that demands urgent solutions for detection and therapy to prevent escalating health, social, and economic impacts. The spike protein (S) of this virus enables binding to the human receptor ACE2, and hence presents a prime target for vaccines preventing viral entry into host cells. The S proteins from SARS and SARS-CoV-2 are similar, but structural differences in the receptor binding domain (RBD) preclude the use
doi:10.3389/fcimb.2020.00405
pmid:32850499
pmcid:PMC7396417
fatcat:seowgiqpxnfkzfia6szqmnewte