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Semantic memory includes all acquired knowledge about the world and is the basis for nearly all human activity, yet its neurobiological foundation is only now becoming clear. Recent neuroimaging studies demonstrate two striking results: the participation of modality-specific sensory, motor, and emotion systems in language comprehension, and the existence of large brain regions that participate in comprehension tasks but are not modality-specific. These latter regions, which include the inferiordoi:10.1016/j.tics.2011.10.001 pmid:22001867 pmcid:PMC3350748 fatcat:z56v7zduuvhcrc4d4qvkxefoqe