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DNA Bendability and Nucleosome Positioning in Transcriptional Regulation
[chapter]
DNA Conformation and Transcription
The placement of nucleosomes along genomic DNA is determined by signals that can be specific or degenerate at the level of sequence; the latter signals are harder to find using conventional methods. In recent years, the development of sophisticated machine learning techniques that can extract subtle phased signals has improved our ability to distinguish between various classes of nucleosome-positioning sequences. Our knowledge of the structural mechanics of free DNA also has reached the point
doi:10.1007/0-387-29148-2_14
fatcat:wr737s2wffbvjk7xo2g5np65dy