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Novel nanostructured lipid carrier for oral delivery of a poorly soluble antimalarial agent lumefantrine: characterization and pharmacokinetics evaluation
2018
MOJ Bioequivalence & Bioavailability
The objective of this study was to design nanostructured lipid carriers (NLC) for the oral delivery of a poorly soluble antimalarial agent lumefantrine (LFN), which could increase the solubility and oral bioavailability of LFN, with the aim to further improve therapeutic efficacy. The lumefantrine-nanostructured lipid carriers (LFN-NLC) were prepared by the method of ultrasonication. Based on the optimized results of single-factor screening experiment, LFN-NLC was found to be relatively uniform
doi:10.15406/mojbb.2018.05.00079
fatcat:sgurtwltaja4rkqnpiuz55eps4