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Circadian vulnerability of cisplatin‐induced ototoxicity in the cochlea
The FASEB Journal
The chemotherapeutic agent cisplatin is renowned for its ototoxic effects. While hair cells in the cochlea are established targets of cisplatin, less is known regarding the afferent synapse, which is an essential component in the faithful temporal transmission of sound. The glutamate aspartate transporter (GLAST) shields the auditory synapse from excessive glutamate release, and its loss of function increases the vulnerability to noise, salicylate, and aminoglycosides. Until now, thedoi:10.1096/fj.202001236r pmid:32840016 fatcat:jdx2vikvojfvtjlihgshpobniu