In recent years, a myriad of neuroimaging studies has investigated the neural basis of emotion regulation (ER), and substantial progress has been made toward building neurally plausible models of ER. However, single studies usually provide limited insight into the function of specific brain regions. Thus, to better understand the role of the amygdala in emotion regulation and the relationship with other brain regions, we performed coordinate-based meta-analysis on studies of emotion regulation

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... elated connectivity of the amygdala which used functional magnetic resonance imaging (fMRI) and psychophysiological interaction (PPI) analysis. Methods Literature research was conducted using PubMed (www.pubmed.com) searching for combinations of keywords "emotion regulation" "affective regulation", "reappraisal", "fMRI", "functional magnetic resonance imaging", "functional MRI", "effective connectivity", "functional connectivity", "PPI" and "psychophysiological interaction analysis". The search was limited to 1st of January to 31st of December 2019 and revealed 196 studies. Based on specific inclusion/exclusion criteria, 17 studies were included in the analysis. The meta-analysis was performed using the revised version1 of the activation likelihood estimation (ALE) algorithm for coordinate-based quantitative meta-analyses of neuroimaging results as implemented in GingerALE 3.0.2. Since the functional lateralization of the amygdala has been well documented, it is possible that the left and right amygdala show different patterns of task modulated connectivity. To explore this, we performed separate ALE analyses. As only 6 studies used the right amygdala as seed for the PPI analysis, we first performed an analysis based on studies using the left amygdala as seed region and then extended this analysis by including the coordinates of studies using the right amygdala as seed region for their analysis. By combining the probabilities of all reported foci [...]