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Tethered primary hepatocyte spheroids on polystyrene multi-well plates for high-throughput drug safety testing
2020
Scientific Reports
Hepatocyte spheroids are useful models for mimicking liver phenotypes in vitro because of their three-dimensionality. However, the lack of a biomaterial platform which allows the facile manipulation of spheroid cultures on a large scale severely limits their application in automated high-throughput drug safety testing. In addition, there is not yet a robust way of controlling spheroid size, homogeneity and integrity during extended culture. This work addresses these bottlenecks to the
doi:10.1038/s41598-020-61699-4
pmid:32179810
fatcat:ve3oemecizazjopv7syp6w766m