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Metabolic effects of the HIV protease inhibitor – saquinavir in differentiating human preadipocytes
2013
Pharmacological Reports
The iatrogenic, HIV-related lipodystrophy is associated with development of the significant metabolic and cardiovascular complications. The underlying mechanisms of antiretroviral (ARV) drugs are not completely explored. Methods: The aim of the study was to characterize effects of the protease inhibitor (PI) -saquinavir (SQV) on metabolic functions, and gene expression during differentiation in cells (Chub-S7) culture. Results: SQV in concentrations observed during antiretroviral therapy (ART)
doi:10.1016/s1734-1140(13)71075-2
pmid:24145088
fatcat:7wqgw5p455finb5plb52wnvedq