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Faster Growth With Shorter Antigens Explains A VSG Hierarchy During African Trypanosome Infections: A Feint Attack By Parasites
[article]
2017
bioRxiv
pre-print
The parasitic African trypanosome, Trypanosoma brucei, evades the adaptive host immune response by a process of antigenic variation that involves the clonal switching of variant surface glycoproteins (VSGs). The VSGs that periodically come to dominate in vivo display a hierarchy, but how this hierarchy arises is not well-understood. Combining publicly available genetic data with mathematical modelling, we report a VSG-length-dependent hierarchical timing of clonal VSG dominance in a mouse
doi:10.1101/131029
fatcat:ilkoi4hexnfz5egyn5k6bfgxqy